April, 2008: 28 (4)
"Special Feature: Cytokines and Inflammation"
[Cover Caption]
Browse Archive
 Commentary | Pages |
|---|---|
| The Roaring Twenties Richard M. Locksley | 437 |
| Cytokines as Therapeutic Targets: Advances and Limitations Clemens Scheinecker, Kurt Redlich, and Josef S. Smolen | 440 |
| Reviews | Pages |
| Th17 Cell Differentiation: The Long and Winding Road Mandy J. McGeachy and Daniel J. Cua | 445 |
| The Biological Functions of T Helper 17 Cell Effector Cytokines in Inflammation Wenjun Ouyang, Jay K. Kolls, and Yan Zheng | 454 |
| Contextual Regulation of Inflammation: A Duet by Transforming Growth Factor-β and Interleukin-10 Ming O. Li and Richard A. Flavell | 468 |
| Cytokine Signaling Modules in Inflammatory Responses John J. O'Shea and Peter J. Murray | 477 |
| Previews | Pages |
| B Cell Development: Important Work for ERK Michael R. Gold | 488 |
| The STATs on Dendritic Cell Development Nobuyuki Onai and Markus G. Manz | 490 |
| Cancer Immunosurveillance: NKG2D Breaks Cover Hans-Gustaf Ljunggren | 492 |
| Basophils Are Back! Stephen J. Galli and Christopher B. Franco | 495 |
| Articles | Pages |
| Erk Kinases Link Pre-B Cell Receptor Signaling to Transcriptional Events Required for Early B Cell Expansion Tomoharu Yasuda, Hideki Sanjo, Gilles Pagès, Yohei Kawano, Hajime Karasuyama, Jacques Pouysségur, Masato Ogata, and Tomohiro Kurosaki | 499 |
| The Signal Transducer STAT5 Inhibits Plasmacytoid Dendritic Cell Development by Suppressing Transcription Factor IRF8 Eiji Esashi, Yui-Hsi Wang, Olivia Perng, Xiao-Feng Qin, Yong-Jun Liu, and Stephanie S. Watowich | 509 |
| Constitutive Crosspresentation of Tissue Antigens by Dendritic Cells Controls CD8+ T Cell Tolerance In Vivo Nancy Luckashenak, Samira Schroeder, Katrin Endt, Darja Schmidt, Karsten Mahnke, Martin F. Bachmann, Peggy Marconi, Cornelia A. Deeg, and Thomas Brocker | 521 |
| Rapid Culling of the CD4+ T Cell Repertoire in the Transition from Effector to Memory Matthew A. Williams, Eugene V. Ravkov, and Michael J. Bevan | 533 |
| Regulatory T Cell-Derived Interleukin-10 Limits Inflammation at Environmental Interfaces Yuri P. Rubtsov, Jeffrey P. Rasmussen, Emil Y. Chi, Jason Fontenot, Luca Castelli, Xin Ye, Piper Treuting, Lisa Siewe, Axel Roers, William R. Henderson, Werner Muller, and Alexander Y. Rudensky | 546 |
| Interleukin-23 Restrains Regulatory T Cell Activity to Drive T Cell-Dependent Colitis Ana Izcue, Sophie Hue, Sofia Buonocore, Carolina V. Arancibia-Cárcamo, Philip P. Ahern, Yoichiro Iwakura, Kevin J. Maloy, and Fiona Powrie | 559 |
| NKG2D-Deficient Mice Are Defective in Tumor Surveillance in Models of Spontaneous Malignancy Nadia Guerra, Ying Xim Tan, Nathalie T. Joncker, Augustine Choy, Fermin Gallardo, Na Xiong, Susan Knoblaugh, Dragana Cado, Norman R. Greenberg, and David H. Raulet | 571 |
| Basophils Play a Pivotal Role in Immunoglobulin-G-Mediated but Not Immunoglobulin-E-Mediated Systemic Anaphylaxis Yusuke Tsujimura, Kazushige Obata, Kaori Mukai, Hideo Shindou, Masayuki Yoshida, Hideto Nishikado, Yohei Kawano, Yoshiyuki Minegishi, Takao Shimizu, and Hajime Karasuyama | 581 |
Cover Caption
On the cover: The cover depicts an image of flames, which abstractly represents the concept of an inflamed immune system. Inflammation can occur in response to pathogen attack or in the context of an autoimmune reaction, and cytokines have a fundamental role in this process. CD4+ T cells such as T helper (Th) cells and T regulatory (Treg) cells are central players in inflammation and the source of many of the cytokines involved. This issue of Immunity presents a series of reviews that discuss the cytokine-mediated differentiation and regulation of Th17 cells (McGeachy and Cua, pp. 445–453), the biological context of Th17-cell-meditated inflammation (Ouyang et al., pp. 454–467), the control of inflammation by transforming growth factor-β and interleukin-10 (Li and Flavell, pp. 468–476), and the intracellular signaling pathways induced by both pro- and anti-inflammatory cytokines (O'Shea and Murray, pp. 477–487). Scheinecker et al. (pp. 440–444) summarize the status of cytokine-based therapeutic approaches to treating inflammatory diseases, and Locksley (pp. 437–439) provides an overview, with a focus on the central role of CD4+ T helper cell subsets in orchestrating inflammation and its control. Printed with permission from Ingram Publishing.
Featured Article
- Th17 Cell Differentiation: The Long and Winding Road
Mandy J. McGeachy and Daniel J. Cua
[Summary] [Full Text] [PDF] - The characterization of the new lineage of IL-17-producing CD4+ T helper (Th17) cells has revolutionized our current understanding of T cell-mediated immunity. Over the past five years, there have been many twists and turns as the pathways that lead to Th17 cell differentiation have been elucidated. Not least of these was the discovery that TGF-β is a crucial cytokine for Th17 cell development, suggesting that Th17 and regulatory T cell subsets share reciprocal developmental pathways during the pathogenesis or control of inflammation. This review aims to bring together the observations that have formed current opinion on factors that promote and contain Th17 cell development, in both mouse and man. Unresolved controversies in this field are also discussed: For example, IL-23 is absolutely required for disease pathogenesis in many models of Th17-cell-mediated autoimmunity, yet its role in Th17 cell development is relatively unclear.
